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BioPhotonics
Conference 2023: October 24-26
OCT
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Join Photonics Media online Oct. 24-26 for the BioPhotonics Conference, a virtual event highlighting innovation in the life sciences and biomedical optics. The conference will feature three keynotes...
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Lock-in Amplifier or Boxcar Averager? Choosing the Right Measurement Tool for Periodic Signals
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When it comes to analyzing periodic signals, selecting the appropriate measurement tool is crucial for achieving accurate and meaningful results. Gustavo Ciardi of Zurich Instruments delves into the...
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Next-Generation Instrumentation for Optical Control and Characterization
NOV
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The characterization and control of optical systems with multiple stand-alone pieces of test equipment often presents difficult challenges that lead to lower stability, more noise, and increased...
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Nanoscale Imaging Techniques
Golshan Coleiny of Fundamental Optical Solutions shares a brief history of nanoscale imaging with a focus on optical technologies, addressing many of today’s challenges in optical limitation...
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Key Considerations in Objective Selection for Machine Vision
Microscope objectives are critical for high magnification machine vision applications such as semiconductor inspection. There are different key considerations when choosing the right objective...
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Revolutionizing Measurements: Next-Generation Strategies for Modern Phase Detection
Liquid Instruments co-founder and CEO Daniel Shaddock shares next-generation strategies to perform optical phase locking using digitally implemented, FPGA-based lock-in amplifiers and phasemeters. He...
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Non-Contact Sub-500 nm IR and Simultaneous Raman Microscopy with Fluorescence Imaging Serves as a New Paradigm in Vibrational Spectroscopy
Optical photothermal infrared (O-PTIR) spectroscopy has established itself as a cutting edge vibrational microspectroscopy tool. It offers significant advantages over traditional FTIR,...
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Raman Microscopy for Pharmaceutical Research and Development: Technique Variations and Software Advances
Raman imaging microscopy is a highly versatile and effective tool for the label-free, nondestructive chemical characterization of materials. Based on the Raman effect, which describes a distinct...
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Quantitative Stimulated Raman Scattering Microscopy: From Molecules to Animals
Stimulated Raman scattering (SRS) microscopy has become a powerful chemical imaging tool that shows significant promise in numerous biological and biomedical applications. In a typical SRS microscopy...
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A User Guide to Image Quality Assessment for Artificial Intelligence
The size and number of images for image acquisition instruments and processing techniques have grown exponentially, along with the associated storage needs and network requirements. In the fields...
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Looking Deeper by Listening to Light: Photoacoustic Imaging and Its Applications
Photoacoustic imaging is a novel hybrid imaging technique that combines both optical and ultrasound imaging. In this technique, a short-pulsed laser source illuminates the tissue to generate sound...
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Harnessing Photons for Bond-Selective Imaging, Neuromodulation, and the Killing of Superbugs
Chemical microscopy that utilizes fingerprint vibrational spectroscopic signals opens a new window to visualizing the orchestra of molecules and biological structures inside living systems. Ji-Xin...
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Cutting-Edge 3D Raman Imaging in the Life Sciences
Raman imaging is a versatile, label-free, and nondestructive microscopy technique that can characterize many types of materials, including biological samples. It provides information about their...
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Ultrafast Tablet Imaging Made Practical with the Novel Use of QCL Sources Coupled with Machine Learning-Based Analysis Algorithms
The composition of pharmaceutical tablets and the distribution of the ingredients therein can be determined using chemical imaging performed by vibrational microscopy. Doing so provides valuable...
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Photoacoustic Remote Sensing: A New Absorption-Based Microscopy for Assessment of Subcellular Structures
Optical absorption is a desirable imaging contrast because a wide variety of biomedical and industrial targets absorb light, including RNA, DNA, blood, lipid, metals, and some gas molecules such as...
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Multiphoton Imaging in Neuroscience
Multiphoton imaging in neuroscience has much evolved from the initial two-photon microscope that Winfried Denk built in Watt Webb’s lab at Cornell University in the late 1980s, which made the...
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Macroscopy FRET FLI Monitors Cancer Drug-Target Engagement in Vivo
The main goal of Barroso and her colleagues’ research is to accelerate preclinical drug discovery by developing novel imaging assays to screen and optimize the delivery of targeted anti-cancer...
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RCM-OCT Enhances Skin Cancer Diagnosis and Therapy Guidance Through Hand-Held Imaging
Advancements in optical imaging in recent years have enabled faster and more reliable noninvasive assessment of skin lesions, especially of basal cell carcinomas. Among various technologies, optical...
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Semantic and Instance Segmentation of Microscopic Images Using Pretrained Neural Networks
Robust segmentation of microscopic images is the foundation for the subsequent analysis of the image content and hence the (biological) properties of the sample. In addition to semantic segmentation,...
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Probes Provide Supermultiplexed Imaging of Tissues and Systems
Biological systems with intrinsic complexity require multiplexing techniques to comprehensively describe the phenotype, interaction, and heterogeneity. However, fluorescence can only image two to...
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KEYNOTE: Deep Learning-Enabled Computational Microscopy and Diffractive Imaging
Ozcan provides an overview of his recent work on using deep neural networks in advancing computational microscopy and sensing systems. He also covers the systems' biomedical applications, including...
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MediSCAPE Microscopy Enables Label-Free, 3D Histological Imaging in Vivo
The microstructure and cellular organization of tissues have been imaged to differentiate between tissue types in their normal and diseased states since the 19th century. However, despite major...
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Multi-Immersion Lenses for Cleared-Tissue Imaging
A simple design trick enables an objective lens to work in any dipping medium, unlike other multi-immersion objectives with limited refractive index range. Daniels describes the design trick and its...
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Multiorgan COVID-19 Autopsy Findings Using 3D Virtual Histology
The study of tissue samples from the organs of individuals who have died as a direct result of acute COVID-19 infection, or its consequences, is vital to our understanding of the pathogenesis of this...
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Selecting the Right Optics for Ultrafast Microscopy
Ultrafast lasers are being increasingly used in life science imaging techniques such as multiphoton microscopy. However, the short pulse durations and high peak powers of ultrafast lasers make...
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