This is the syndication feed for photonics.com: Biophotonics. https://www.photonics.com/Splash.aspx?Tag=Biophotonics Mon, 09 Oct 2023 21:52:49 GMT Mon, 09 Oct 2023 07:00:00 GMT 1800
Therapy-induced senescent (TIS) cells are cancer cells that become resistant to therapies and enter a dormant stage. These cells can emerge from dormancy and induce tumor resistance and relapse. To provide insight into how TIS cells evolve, it is crucial to develop simple, reproducible methods to study the onset and progression of these cells in human cancer cell cultures.

An international team from Johns Hopkins University and Italy’s Politecnico di Milano, Fondazione Istituto Nazionale dei Tumori, and Consiglio Nazionale delle Ricerche developed a noninvasive, multimodal imaging technique to allow early identification of TIS cells. The new technique could improve clinical outcomes by enabling more comprehensive research into...]]> https://www.photonics.com/Articles/Microscopy_Methods_Combine_to_Detect/a69380 A69380 Mon, 09 Oct 2023 07:00:00 GMT
The researchers used indirect OLED pumping to power the laser. They built an integrated device structure that efficiently coupled an OLED that had very high light output with a polymer-based, distributed feedback laser.

Most organic semiconductor lasers are optically pumped by another laser — a complicated, expensive process. Electrical pumping, which involves injecting a current to generate a population inversion, is challenging to achieve in organic...]]> https://www.photonics.com/Articles/OLEDs_Could_Be_Solution_to_Electrically_Driven/a69376 A69376 Fri, 06 Oct 2023 07:00:00 GMT
The Science and Technology Facilities Council (STFC) Central Laser Facility (CLF) was awarded £85 million ($103.2 million) by UK Research and Innovation for an upgrade initiative that includes construction of the Vulcan 20-20 laser, which is set to be the most powerful laser in the world.
The CLF’s Vulcan laser will receive a significant upgrade that will bring the laser’s energy output to 20 PW. The upgrade will take place over the course of six years. Courtesy of the Science and Technology Facilities Council. CLF, based at the STFC Rutherford Appleton Laboratory, uses a suite of lasers to generate plasma. The most powerful of the CLF’s lasers is Vulcan, with Vulcan 20-20 expected to be 100 times brighter than...]]> https://www.photonics.com/Articles/UKs_Central_Laser_Facility_Receives_Over_100M/a69372 A69372 Thu, 05 Oct 2023 07:00:00 GMT
Postpartum hemorrhage, the leading and most preventable cause of maternal mortality, can be hard to detect, because physiological compensation mechanisms can mask excessive bleeding. In the early stages of hemorrhage, the sympathetic nervous system becomes activated to ensure adequate perfusion of vital organs and, in turn, vital signs remain stable.

Worldwide, the most common methods of diagnosing postpartum hemorrhage are visual estimation of blood loss or monitoring of vital signs. Blood loss is routinely underestimated beyond the point of early intervention.

To diagnose postpartum hemorrhage in its early stages, a multidisciplinary research team at Washington University in St. Louis developed a wearable optical device that...]]> https://www.photonics.com/Articles/Wearable_Sensor_Could_Lower_Mortality_Due_to/a69365 A69365 Tue, 03 Oct 2023 07:00:00 GMT
In 2000, Berthold Leibinger, the man who brought laser technology into Germany’s TRUMPF Group, established the Innovation Award — expressed in native German as the “Innovationspreis” — to honor outstanding R&D in the field of laser technology. Next to this prestigious award, the Berthold Leibinger Zukunftspreis was added in 2006 to recognize scientists driving fundamental laser research to new heights.

Leibinger sadly passed away a few weeks after the Innovationspreis ceremony in 2018, but he had handed the company over to his children years before, along with the Berthold Leibinger Foundation and its associated awards.

At the 2023 ceremony, held on September 22 in Ditzingen, the Foundation...]]> https://www.photonics.com/Articles/Berthold_Leibinger_Awards_Honor_Laser_Research_at/a69354 A69354 Tue, 26 Sep 2023 09:45:00 GMT
SLAC National Accelerator Laboratory reported that the Linac Coherent Light Source (LCLS) x-ray free-electron laser (XFEL) has produced its first x-rays following a $1.1 billion upgrade. The improvements, more than 10 years in the making, allow the laser to fire up to a million x-ray flashes per second, which is 8000 times more than its predecessor. The generated, almost-continuous x-ray beam will be 10,000 times brighter than its predecessor on average.

LCLS-II will enable researchers to explore the details of quantum materials with unprecedented resolution to drive new forms of computing and communications; reveal unpredictable and fleeting chemical events relevant to sustainable energy; study how biological molecules carry out...]]> https://www.photonics.com/Articles/SLACs_Upgraded_XFEL_Registers_First_Light/a69343 A69343 Thu, 21 Sep 2023 07:00:00 GMT
An on-demand optical system for exporting target droplets from a static droplet array (SDA) provides a simple way to export specific cells or analytes for analysis without compromising efficiency or accuracy. Researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences developed the system, called optical on-demand droplet release (OODR). The developers and their collaborators believe that OODR could promote SDAs as a valuable tool for use with high-capacity screening assays with applications in diverse fields. They said that the technique in its current stage of development has the potential to be used in single-molecule/cell analysis, drug screening, and phenotype-based cell sorting.

...]]> https://www.photonics.com/Articles/Single-Cell_Analysis_Fluidics_Tool_Delivers_on/a69339 A69339 Wed, 20 Sep 2023 07:00:00 GMT
Michael Ersoni, Excelitas’ executive vice president of commercial business, noted the complementary nature of both companies’ technologies — notably, Heraeus...]]> https://www.photonics.com/Articles/Excelitas_Technologies_to_Acquire_Heraeus/a69331 A69331 Fri, 15 Sep 2023 13:35:57 GMT
A multispectral, super-low-dose photoacoustic microscopy (SLD-PAM) system developed by City University of Hong Kong (CUHK) achieves significantly higher sensitivity than traditional optical resolution photoacoustic imaging.

By providing an exceptionally high level of sensitivity, SLD-PAM could help broaden the use of photoacoustic microscopy in biomedical applications. In the future, it could translate to clinical settings; for example, it could be used for ophthalmic exams where a low-power laser is preferred for the patient’s safety and comfort. Long-term monitoring of pharmacokinetics or blood flow also requires low-dose imaging to alleviate perturbation to tissue function.
(a) SLD-PAM system and (b) sensitivity...]]> https://www.photonics.com/Articles/Super-Sensitive_PAM_Ensures_Image_Quality_with/a69327 A69327 Fri, 15 Sep 2023 07:00:00 GMT
The ability to image complex biological tissues is essential for many biological studies and clinical diagnostic applications. However, capturing detailed 3D images of thick biological samples is difficult, due to multiple light-scattering in the samples.

Optical diffraction tomography is still largely restricted to imaging thin objects such as cells and thin tissue slices. To allow for in vivo imaging with extended imaging depth, a full-field, reflection-mode measurement geometry needs to be implemented. Also, a comprehensive inverse-scattering model that accounts for the temporal dispersion and spatial aberration of the back-scattered field from thick, inhomogeneous media needs to be developed. In addition, the multiple-scattering...]]> https://www.photonics.com/Articles/Tomography_Technique_Images_Thick_Bio_Samples_at/a69307 A69307 Fri, 08 Sep 2023 07:00:00 GMT
Axithra, a spinout of imec and Ghent University, has raised €10 million ($10.7 million) in a seed round to develop a chip-based Raman spectroscopy platform to monitor drug concentration in the blood to enable timely adjustments of dosages where necessary. The seed round, which saw backing from Hamamatsu, secures the first two years of research and development.

According to Roel Baets, a professor in the Photonics Research Group, an associated imec lab at Ghent University, the integration of Raman spectroscopy onto a photonic chip makes the technique far more sensitive.

As a first application, the spinoff will deploy its technology to measure the concentration of beta-lactam antibiotics in a patient’s blood. This...]]> https://www.photonics.com/Articles/Ghent_University_imec_Spinout_Axithra_Raises_10M/a69299 A69299 Thu, 07 Sep 2023 07:00:00 GMT
Researchers from Pohang University of Science and Technology (POSTECH) have developed optical sensor technology to aid patients with limited mobility during their rehabilitation. The sensor integrates computer vision technology to help track muscle movements.

Wearable devices such as smartwatches, smart eyewear, and, to an extent, smartphones can be vital for tracking health. Many have built-in functions like step counters and heart-rate monitors.

Other devices, like wearable robots, use strain sensors to analyze data by translating specific physical changes in specific regions into electric signals. These sensors are flexible, lightweight, and adept at gauging subtle bodily changes. Still, conventional soft strain sensors...]]> https://www.photonics.com/Articles/Computer_Vision_Enhanced_Sensors_Aid/a69292 A69292 Tue, 05 Sep 2023 07:00:00 GMT
SPIE will launch Biophotonics Discovery, the 15th publication from the society. The journal will serve as a peer-reviewed outlet for research presented at the Photonics West BiOS Symposium, SPIE said.

The journal will complement the society’s other biomedical journals: Journal of Biomedical Optics (JBO), which focuses primarily on optical-device development; Journal of Medical Imaging (JMI); and Neurophotonics. Biophotonics Discovery will cover the entire breadth of the BiOS symposium’s topics, including the more application-specific conferences, which previously did not have a clear peer-reviewed journal outlet with SPIE.

Biophotonics Discovery will open to submissions later this year, with the inaugural issue...]]> https://www.photonics.com/Articles/SPIE_Launches_New_Biophotonics_Journal/a69295 A69295 Tue, 05 Sep 2023 07:00:00 GMT
According to the World Health Organization, 17.9 million people die annually due to cardiovascular diseases. Soft wearable devices are well suited for monitoring physiological signals from electrocardiogram, phonocardiogram, and pulse wave. Advantages of these types of devices include real-time operation capability, skin-like mechanical properties, and high signal-to-noise sensing capability.

However, monolithic hemodynamic parameters achieved by current wearable devices cannot adequately and precisely reflect the health status of regional vasculature. Spatiotemporal hemodynamic monitoring techniques are needed to satisfy growing demand for clinical treatment and daily health management of the cardiovascular system.

Researchers...]]> https://www.photonics.com/Articles/Skin-Like_Microfiber_Grating_Gauges/a69288 A69288 Thu, 31 Aug 2023 07:00:00 GMT
The trials are set to span the next two years. Peter Soto, who is director of the MIT LBRC, and MIT’s Jeon Woong Kang and Apollon’s Youngkyu Kim will lead the effort. Kang, in previous research, demonstrated direct measurements of glucose concentration without drawing blood by irradiating the skin of pig test subjects with laser light. The...]]> https://www.photonics.com/Articles/Apollon_MIT_to_Collaborate_on_Noninvasive/a69279 A69279 Mon, 28 Aug 2023 07:00:00 GMT
Thermo Fisher Scientific completed the acquisition of CorEvitas LLC, a provider of regulatory-grade, real-world evidence for approved medical treatments and therapies, for $912.5 million in cash. CorEvitas will become part of Thermo Fisher’s Laboratory Products and Biopharma Services segment, having been a partner to pharma and biotech customers for more than 20 years. CorEvitas manages 12 registries, including nine autoimmune and inflammatory syndicated registries.

VIENNA — Smart glasses developer Viewpointsystem and micro-optical components manufacturer Printoptix were awarded a grant of €2.5 million ($2.7 million) by the European Innovation Council for their cooperation project called 3DPrintoptixMarket. The...]]> https://www.photonics.com/Articles/Viewpointsystem_Printoptix_Receive_25M_Week/a69277 A69277 Fri, 25 Aug 2023 07:00:00 GMT
The first study successfully demonstrated intra-subject tracking of blood pressure compared to measurements using an intra-arterial pressure transducer, or an A-line, which is the gold-standard method to continuously monitor blood pressure during surgery and in the ICU. The study looked at 30 subjects who induced blood pressure changes using a repeated leg press exercise.

Using only the Rockley laser-based signal and a single-point blood pressure calibration, blood pressure changes from −10 to 25 mmHg were...]]> https://www.photonics.com/Articles/Rockley_Completes_Human_Studies_of_Blood_Pressure/a69272 A69272 Thu, 24 Aug 2023 07:00:00 GMT
Researchers at Boston University (BU) developed two new IDT methods — annular IDT (aIDT) and multiplexed IDT (mIDT) — to boost the image acquisition speed in 3D imaging techniques. Annular IDT uses an LED ring that matches the objective’s numerical aperture (NA). Multiplexed IDT uses multiple LEDs that illuminate the sample simultaneously. Both IDT methods improve 3D imaging speed enough to enable visualization...]]> https://www.photonics.com/Articles/Tomography_Techniques_Recover_Scattered_Light_to/a69267 A69267 Thu, 24 Aug 2023 07:00:00 GMT
A research team led by professor Aydogan Ozcan at the University of California, Los Angeles (UCLA) developed a deep-learning-based approach to designing spatially incoherent, diffractive optical processors. The method provides a way to build all-optical visual processors that work under natural light. Following deep learning, the diffractive optical processors can transform any input light intensity pattern into the correct output pattern.

The researchers believe that their design for diffractive optical processors will have broad application, in addition to contributing to the quest for a fast, energy-efficient alternative to electronic computing for future computing needs.

Since natural lighting conditions typically involve...]]> https://www.photonics.com/Articles/Optical_Processor_Captures_Scenes_in_Spatially/a69258 A69258 Tue, 22 Aug 2023 07:00:00 GMT
PhenomeX provides single-cell biology research tools to deliver insights into cellular function and perspectives on phenomes and genotype-to-phenotype linkages. Its solutions include the Beacon optofluidics platform, as well as the IsoLight and IsoSpark proteomics barcoding platform. The Beacon product enables functional characterization of tens of thousands of single cells in parallel, while maintaining the cells in a healthy state for further genomic and proteomic profiling, connecting phenotype with...]]> https://www.photonics.com/Articles/Bruker_Enters_New_Research_Space_with_PhenomeX/a69253 A69253 Fri, 18 Aug 2023 07:00:00 GMT