This is the syndication feed for photonics.com: Microscopy. https://www.photonics.com/Splash.aspx?Tag=Microscopy Mon, 09 Oct 2023 21:57:22 GMT Mon, 09 Oct 2023 07:00:00 GMT 1800
Therapy-induced senescent (TIS) cells are cancer cells that become resistant to therapies and enter a dormant stage. These cells can emerge from dormancy and induce tumor resistance and relapse. To provide insight into how TIS cells evolve, it is crucial to develop simple, reproducible methods to study the onset and progression of these cells in human cancer cell cultures.

An international team from Johns Hopkins University and Italy’s Politecnico di Milano, Fondazione Istituto Nazionale dei Tumori, and Consiglio Nazionale delle Ricerche developed a noninvasive, multimodal imaging technique to allow early identification of TIS cells. The new technique could improve clinical outcomes by enabling more comprehensive research into...]]> https://www.photonics.com/Articles/Microscopy_Methods_Combine_to_Detect/a69380 A69380 Mon, 09 Oct 2023 07:00:00 GMT
Monroe Community College received a $5.1 million grant from the Department of Defense’s Manufacturing Engineering Education Program (MEEP) to fund its optics and photonics associate degree programs. The funding is part of $53 million recently distributed by the National Defense Education Program to 13 organizations. This is the second time Monroe has been awarded funding through the MEEP program, as the nation’s first community college to administer associate degrees in precision optics.

The collaboration will use ASMPT’s hardware and Teramount’s optical elements. Courtesy of Teramount.
REGENSBURG, Germany — ASMPT AMICRA, a supplier of ultrahigh-precision die attach equipment, and Teramount Ltd., a...]]> https://www.photonics.com/Articles/Monroe_CC_Awarded_5M_by_DOD_ASMPT_AMICRA/a69363 A69363 Fri, 29 Sep 2023 07:00:00 GMT
A multispectral, super-low-dose photoacoustic microscopy (SLD-PAM) system developed by City University of Hong Kong (CUHK) achieves significantly higher sensitivity than traditional optical resolution photoacoustic imaging.

By providing an exceptionally high level of sensitivity, SLD-PAM could help broaden the use of photoacoustic microscopy in biomedical applications. In the future, it could translate to clinical settings; for example, it could be used for ophthalmic exams where a low-power laser is preferred for the patient’s safety and comfort. Long-term monitoring of pharmacokinetics or blood flow also requires low-dose imaging to alleviate perturbation to tissue function.
(a) SLD-PAM system and (b) sensitivity...]]> https://www.photonics.com/Articles/Super-Sensitive_PAM_Ensures_Image_Quality_with/a69327 A69327 Fri, 15 Sep 2023 07:00:00 GMT
The ability to image complex biological tissues is essential for many biological studies and clinical diagnostic applications. However, capturing detailed 3D images of thick biological samples is difficult, due to multiple light-scattering in the samples.

Optical diffraction tomography is still largely restricted to imaging thin objects such as cells and thin tissue slices. To allow for in vivo imaging with extended imaging depth, a full-field, reflection-mode measurement geometry needs to be implemented. Also, a comprehensive inverse-scattering model that accounts for the temporal dispersion and spatial aberration of the back-scattered field from thick, inhomogeneous media needs to be developed. In addition, the multiple-scattering...]]> https://www.photonics.com/Articles/Tomography_Technique_Images_Thick_Bio_Samples_at/a69307 A69307 Fri, 08 Sep 2023 07:00:00 GMT
Researchers at Boston University (BU) developed two new IDT methods — annular IDT (aIDT) and multiplexed IDT (mIDT) — to boost the image acquisition speed in 3D imaging techniques. Annular IDT uses an LED ring that matches the objective’s numerical aperture (NA). Multiplexed IDT uses multiple LEDs that illuminate the sample simultaneously. Both IDT methods improve 3D imaging speed enough to enable visualization...]]> https://www.photonics.com/Articles/Tomography_Techniques_Recover_Scattered_Light_to/a69267 A69267 Thu, 24 Aug 2023 07:00:00 GMT
A research team led by professor Aydogan Ozcan at the University of California, Los Angeles (UCLA) developed a deep-learning-based approach to designing spatially incoherent, diffractive optical processors. The method provides a way to build all-optical visual processors that work under natural light. Following deep learning, the diffractive optical processors can transform any input light intensity pattern into the correct output pattern.

The researchers believe that their design for diffractive optical processors will have broad application, in addition to contributing to the quest for a fast, energy-efficient alternative to electronic computing for future computing needs.

Since natural lighting conditions typically involve...]]> https://www.photonics.com/Articles/Optical_Processor_Captures_Scenes_in_Spatially/a69258 A69258 Tue, 22 Aug 2023 07:00:00 GMT
Evident Corp. appointed William Wesley “Wes” Pringle CEO and Hiroyuki Yoshimoto president and COO as the life science and industrial microscopes manufacturer reworks its leadership group. Olympus, which held Evident as a subsidiary and operated it as its Scientific Solutions business, announced plans to divest Evident to Bain Capital in August 2022 in a deal worth over $3 billion. The deal was finalized in April this year.

Pringle joins Evident from Danaher, where he ran several companies including test and measurement technology developer Fluke Corp. for almost 10 years. More recently, Pringle served as head of portfolio operations at the private equity firm Onex Corp., where he helped over a dozen portfolio companies...]]> https://www.photonics.com/Articles/Evident_Corp_Appoints_Leadership_Team/a69248 A69248 Wed, 16 Aug 2023 07:00:00 GMT
A research group from Japan Advanced Institute of Science and Technology (JAIST) developed light-activatable, liquid metal (LM) nanoparticles for cancer diagnosis and treatment via photoimmunotherapy. The LM nanoparticles can target and destroy cancer cells and can be fluorescently tagged to function as reporters to identify and eliminate tumors in vivo.

Gallium (Ga)-based LM nanoparticles are promising nanoscale materials for biomedical applications due to their physicochemical properties, including flexibility, easy surface modification, efficient photothermal conversion, and high biocompatibility.

One prominent application of LMs is photothermal cancer therapy, in which functional LM nanoparticles convert light energy to heat...]]> https://www.photonics.com/Articles/Light-Triggered_Particles_Deliver/a69243 A69243 Tue, 15 Aug 2023 07:00:00 GMT
Lidar developer Hesai Technology collaborated with NVIDIA to integrate Hesai’s AT128 automotive-grade, ultrahigh-resolution long-range lidar into the NVIDIA DRIVE and NVIDIA Omniverse ecosystems. Hesai’s AT128 lidar comprises128 independent VCSEL laser transmitters, achieving 1.53 million data points per second and a detection range of 200 m. NVIDIA DRIVE and Omniverse comprise AI, simulation, and software development platforms relevant to the autonomous driving industry and its development.

CAMBRIDGE, England — Kubos Semiconductors, a microLED material technology company, won a £700,000 ($889,171) Future Economy Investor Partnerships grant from Innovate UK. The grant is for a 24-month project to achieve 5%...]]> https://www.photonics.com/Articles/Red_MicroLED_Developer_Secures_Funding_Hesai/a69213 A69213 Fri, 04 Aug 2023 07:00:00 GMT
SPIE has added 89 new senior members from academia, industry, and government, from across 17 countries. The members work in a variety of disciplines, including nanophotonics, quantum optics, biomedical engineering, free space optical communications, optical microscopy, optical systems engineering, medical imaging, lidar, machine learning, optoelectronic devices, micro-structured optical fiber technology, astronomical optics, and lithography.

SPIE senior members are society members of distinction who are recognized for their professional experience and technical accomplishments, for their active involvement with the optics community and with SPIE, and for significant performance that sets them apart from their peers. For more...]]> https://www.photonics.com/Articles/SPIE_Adds_89_Senior_Members/a69217 A69217 Fri, 04 Aug 2023 07:00:00 GMT
Scientists at Institute of Science and Technology Austria (ISTA) have developed an imaging technology to analyze live brain tissue at a scope and spatial resolution that, according to the researchers, was not previously possible.

The technology, called Live Information Optimized Nanoscopy Enabling Saturated Segmentation (LIONESS), integrates optical methods and deep learning to allow dense, 4D, nanoscale reconstruction of living brain tissue. LIONESS images and reconstructs the sample in a way that clarifies many dynamic structures and functions in the live tissue. The method unites live imaging with nanoscale reconstruction, extending tissue analysis with information on morphological dynamics, molecular identities, and neuronal...]]> https://www.photonics.com/Articles/Brain_Imaging_Image_Reconstruction_Combine_in_a/a69168 A69168 Tue, 18 Jul 2023 07:00:00 GMT
To improve the study of the pathological processes of cancer cells, researchers at Beijing Institute of Technology combined divided-aperture laser differential confocal microscopy with Raman spectroscopy and Brillouin spectroscopy. The researchers showed that their multichannel, microspectroscopic tool improves the spatial resolution of confocal microscopy and the detection accuracy of Raman and Brillouin spectroscopy for the study of human cells and tissues.

The technique, which the researchers call divided-aperture laser differential confocal Raman-Brillouin spectrum microscopy (DLDCRBSM), simultaneously detects multidimensional information, including 3D geometrical morphology, Raman spectrum, and Brillouin spectrum, in situ, in...]]> https://www.photonics.com/Articles/Multimodal_Microspectroscopic_Approach_Targets/a69165 A69165 Mon, 17 Jul 2023 07:00:00 GMT
The complementary strengths of fluorescence and vibrational microscopy are combined in a new technique developed at Caltech, which is called bond-selective fluorescence-detected infrared-excited spectro-microscopy (BonFIRE). BonFIRE will benefit biological investigations by providing researchers with rich chemical information as well as single-molecule sensitivity.

“With our new microscope, we can now visualize single molecules with vibrational contrast, which is challenging to do with existing technologies,” researcher Dongkwan Lee said.

Fluorescence microscopy allows researchers to observe single molecules, but it does not provide detailed chemical information about molecular distributions. Vibrational microscopy...]]> https://www.photonics.com/Articles/Microscopy_Method_Uses_Infrared_Light_to_Image/a69144 A69144 Fri, 07 Jul 2023 07:00:00 GMT
Resolve Optics installed and commissioned a new vibration test center adding to the suite of in-house lens-testing equipment the company is able to offer. Lenses used in harsh industrial inspection and military and space applications are often exposed to vibrations, shocks, temperature changes, radiation, and contaminants. The company’s new ETS MPA101-L215M Shaker, coupled with a DTC Venzo 880 controller, is certified and calibrated in accordance with ISO standards, which enables Resolve Optics to not only carry out all the common forms of vibration testing, but also undertake specialist vibration/shock qualification tests in accordance with customer requirements.
Resolve Optics’ new ETS MPA101-L215M vibratory shaker coupled...]]> https://www.photonics.com/Articles/Resolve_Optics_Opens_Test_Center_Week_in_Review/a69145 A69145 Fri, 07 Jul 2023 07:00:00 GMT
Electron spins could become more efficient and easier to manage through a light-based approach using halide perovskite semiconductors. Research teams at Harvard’s Rowland Institute and the University of Cambridge observed ultrafast spin-domain formation in polycrystalline halide perovskite thin films in response to irradiating the films with circularly polarized light at room temperature.

Photoinduced spin-charge interconversion in semiconductors, with spin-orbit coupling, could provide a route to spintronics that does not require external magnetic fields, which are challenging to control. An electron can have two spin states, up or down, and these states can be used to store and process information. But manipulating spin...]]> https://www.photonics.com/Articles/Optically_Addressed_Spintronics_Eliminates_Need/a69140 A69140 Wed, 05 Jul 2023 07:00:00 GMT
Researchers from Rice University and University of Maryland have created full-motion video technology that could enable cameras to peer through fog, smoke, driving rain, murky water, skin, bone, and other media that reflect scattered light and obscure objects from view.

According to Ashok Veeraraghavan, professor of electrical and computer engineering at Rice University, imaging through scattering media is the “holy grail problem” in optical imaging. “Scattering is what makes light — which has lower wavelength, and therefore gives much better spatial resolution — unusable in many, many scenarios. If you can undo the effects of scattering, then imaging just goes so much further.”

...]]> https://www.photonics.com/Articles/Video_Tech_Enables_Imaging_Through_Scattering/a69137 A69137 Tue, 04 Jul 2023 07:00:00 GMT
An optical isolator developed at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) could drastically improve optical systems for many practical applications.

Many optical systems, such as those used for telecommunications, microscopy, imaging, quantum photonics, and more, rely on a laser to generate photons and beams of light. To prevent those lasers from damage and instability, these systems also require isolators, which are components that prevent light from traveling in undesired directions. Isolators also help cut down on signal noise by preventing light from bouncing around unfettered. But conventional isolators have been relatively bulky in size and require more than one type of material to be joined...]]> https://www.photonics.com/Articles/Optical_Isolator_Guards_Against_Unwanted/a69133 A69133 Fri, 30 Jun 2023 07:00:00 GMT
ADVA Optical Networking SE’s proposed name change to Adtran Networks SE was approved by the 2023 Annual General Meeting of ADVA Optical Networking SE on May 24. The change was registered in the commercial register of the local court of Jena, Germany, on June 8. The name change is a further step for the combination between ADVA and Adtran Holdings, which began with the conclusion of the business combination agreement between the companies in 2021.
A $57.3 million research initiative has been launched at the National University of Singapore (NUS) to boost innovation and research on advanced solar cell technologies in Singapore. Over the next five years, the REC@NUS Corporate R&D Laboratory for Next Generation Photovoltaics will...]]> https://www.photonics.com/Articles/ADVA_Rebrands_as_Adtran_Networks_SE_Swave/a69116 A69116 Fri, 23 Jun 2023 07:00:00 GMT
Since many core components of cells — like DNA, RNA, proteins, and lipids — are just a few nanometers in size and substantially smaller than the resolution limit of traditional light microscopy, the exact composition and arrangement of these molecules and structures is thus often unknown. This results in a lack of mechanistic understanding of fundamental aspects of biology.

Drawing on recent improvements to superresolution imaging, including single-molecule localization microscopy, or SMLM, researchers from the Max Planck Institute of Biochemistry and Ludwig-Maximilians-Universität Munich have developed a technique that enhances the resolution of fluorescence microscopy down to the angstrom scale. The...]]> https://www.photonics.com/Articles/DNA-Barcoded_Fluorescence_Imaging_Illuminates/a69081 A69081 Tue, 13 Jun 2023 07:00:00 GMT
In cell biology and medical imaging, the targeted manipulation of cells under controlled conditions is a major challenge in understanding processes and causal relationships. Researchers are dependent on tools that enable them to manipulate individual components of a cell in order to explore their effects on intracellular mechanisms and interactions. However, a common problem with conventional methods of cell manipulation is that the sample is disturbed by the manipulation and the results are therefore compromised.

A laser technology developed by researchers at the Max Planck Institute of Molecular Cell Biology and Genetics makes it possible to influence and specifically control movements within living cells and embryos. The...]]> https://www.photonics.com/Articles/Cell_Manipulation_Technique_Enters_into/a69027 A69027 Tue, 23 May 2023 07:00:00 GMT